Tennessee vs Iowa State

Fri, Mar 27, 2026 | 10:00P EST
NCAA Tournament. Sweet 16. United Center. Chicago, IL.
Point Spread Game
Tennessee
Iowa State
Team Total Game
Tennessee
Iowa State
Odds Format

Iowa State vs Tennessee Odds – College Basketball Lines

Iowa State vs Tennessee Betting Analysis

Iowa State is one of two teams from Iowa in the Sweet 16, the other being the Hawkeyes. Impressive stuff.
The key here is to grab Iowa State as a 4-point favorite in college basketball odds if one thinks Joshua Jefferson’s ability to play will/won’t impact the Cyclones’ chances. Jefferson averages 16.4 ppg, 7.4 rpg, and 4.8 apg.

He has an ankle injury that kept him out of the win over Kentucky. Still, the Hawkeyes rolled the Wildcats by 19 points.
Jefferson will have an MRI on Monday to see the extent of the injury. Tennessee waltzed past Miami of Ohio before upending Virginia.

One begins to think the ACC is not all it is cracked up to be this season. If Jefferson gets the okay, the line could bubble up.
If he is out, it should stay around its current mark. Look for the Cyclones to win outright. Just a better team than Tennessee, which already has 11 losses.

Pick: Iowa State minus-4 points


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