College Football Odds

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College Football

Thu, Aug 28, 2025 EST

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Team
Point Spread
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Team Total

Fri, Aug 29, 2025 EST

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Team
Point Spread
Moneyline
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Team Total

Sat, Aug 30, 2025 EST

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Team
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Moneyline
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Mon, Sep 01, 2025 EST

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Team
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Team Total

College Extra

Thu, Aug 28, 2025 EST

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Team
Point Spread
Moneyline
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Team Total
308921
St. Francis (PA)
EXTRA GAME

College Fcs

Thu, Aug 28, 2025 EST

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Team
Point Spread
Moneyline
Total
Team Total
308935
Towson
308936
Norfolk St
FCS
308937
Lindenwood
308938
St Thomas
FCS
308939
Dayton
308940
Eastern Illinois
FCS
308941
West Georgia
308942
Samford
FCS
308943
Alcorn St
308944
Northwestern State
FCS
Odds Format

2025 Week 1 College Football Odds: Spreads, Moneylines and Totals

The wait is finally over. College football is back, and BetUS has you covered with the earliest lines and most competitive odds for every Week 0 and Week 1 showdown. From the opening kickoff in Dublin, Ireland, to the blockbuster matchups on Labor Day weekend, this is your headquarters for betting on every spread, moneyline, and total. Analyze the opening lines, track market movements, and lock in your value picks before the public money pours in. At BetUS, America’s Favorite Sportsbook, the 2025 season starts now.

How to Bet on College Football at BetUS

Betting on NCAA Football is simple. Find the game you want, choose your bet type, and get in on the action. Here are the most popular ways to wager:

NCAAF Point Spreads

This is the ultimate equalizer. Bet on the favorite to win by more than the point spread (e.g., -6.5) or take the underdog to win outright or lose by less than the spread (e.g., +6.5).

NCAAF Moneylines

The purest bet in sports: simply pick the team you believe will win the game straight-up. The odds reflect the probability of victory, offering bigger payouts for underdog upsets.

NCAAF Totals (Over/Under)

Forget picking a side. Bet on the combined final score of both teams. Wager on whether the total points will go Over or Under the number set by the oddsmakers at BetUS.

2025 Week 1 CFB Marquee Matchups

College Football Week 1 delivers a slate of powerhouse non-conference battles. All eyes will be on Columbus as Texas travels to face Ohio State in a seismic clash of titans. Down south, two new-look programs meet when LSU visits Clemson, and the classic rivalry between Notre Dame and Miami is renewed. Don’t miss other premier matchups like Alabama at Florida State and Auburn at Baylor. 

Thursday, Aug. 28

  • Boise State at South Florida | 5:30 p.m. ET | ESPN
  • Delaware State at Delaware | 7 p.m. ET | ESPN+
  • Nebraska vs. Cincinnati (in Kansas City, Missouri) | 9 p.m. ET | ESPN
  • Towson at Norfolk State | Time TBA | ESPN+

Friday, Aug. 29

  • Duke’s Mayo Classic: Appalachian State vs. Charlotte (at Bank of America Stadium in Charlotte, North Carolina) | 7 p.m. ET | ESPNU
  • Auburn at Baylor | 8 p.m. ET | FOX
  • Georgia Tech at Colorado | 8 p.m. ET | ESPN

Saturday, Aug. 30

  • Aflac Kickoff Game: Syracuse vs. Tennessee (in Atlanta, GA) | 12 p.m. ET | ABC
  • Texas at Ohio State | 12 p.m. ET | Fox
  • Duquesne at Pitt | 12 p.m. ET | ACC Network
  • Alabama at Florida State | 3:30 p.m. ET | ABC
  • Montana State at Oregon | 4 p.m. ET | Big Ten Network
  • LSU at Clemson | 7:30 p.m. ET | ABC
  • North Carolina A&T at Tennessee State | ESPN+
  • Eastern Washington at UIW | ESPN+
  • Hampton at Jackson State

Sunday, Aug. 31

  • Aflac Kickoff Game: South Carolina vs. Virginia Tech (in Atlanta, GA) | 3 p.m. ET | ESPN
  • Notre Dame at Miami (FL) | 7:30 p.m. ET | ABC

Monday, Sept. 2

  • TCU at North Carolina | 8 p.m. ET | ESPN

Every game is an opportunity. Find your edge at BetUS today.

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More College Football Betting News

Fund this wager using a pending wager!

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Rolling If Bets (RIF) allow you to use the balance (amount) from existing wagers to make a new wager. As long as existing wagers have not been graded, the amount wagered can still be used to make new wagers. However, if your original wager loses, the Rolling If Bet is then cancelled. There are two options for ties (pushes); you can specify if you want the Rolling If Bet to continue in case of a tie or simply cancel the RIF.

Rolling If Bets are:

  • only allowed on straight bets, Parlays and Teasers.
  • not available with Free Plays or Futures and Props
  • only available if you have pre existing, non graded wagers
  • you can only use the funds from the amount of the pre existing wager

How to Place a Rolling If Bet:

  • Choose any straight, parlay or teaser and Place it on the Bet Slip
  • Click on the Rolling If Bet button next to the wager detail
  • In the RIF dropdown, choose a wager that you want to use for RIF
  • Click on "If Win Only" or "If Win or Push" (explained above)
  • Fill in the amount and confirm your wager (the system will not allow you a higher amount than what is available)
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Fund this wager using a pending wager!

More Details...

Rolling If Bets (RIF) allow you to use the balance (amount) from existing wagers to make a new wager. As long as existing wagers have not been graded, the amount wagered can still be used to make new wagers. However, if your original wager loses, the Rolling If Bet is then cancelled. There are two options for ties (pushes); you can specify if you want the Rolling If Bet to continue in case of a tie or simply cancel the RIF.

Rolling If Bets are:

  • only allowed on straight bets, Parlays and Teasers.
  • not available with Free Plays or Futures and Props
  • only available if you have pre existing, non graded wagers
  • you can only use the funds from the amount of the pre existing wager

How to Place a Rolling If Bet:

  • Choose any straight, parlay or teaser and Place it on the Bet Slip
  • Click on the Rolling If Bet button next to the wager detail
  • In the RIF dropdown, choose a wager that you want to use for RIF
  • Click on "If Win Only" or "If Win or Push" (explained above)
  • Fill in the amount and confirm your wager (the system will not allow you a higher amount than what is available)
Close