A highly anticipated interconference matchup highlights the NFL Week 4 schedule as the Denver Broncos travel to Levi’s Stadium to take on the San Francisco 49ers. NFL odds have the 49ers as 3-point home favorites at -3 (-110), while the Broncos are +3 (-110) on the road. The total is set at 44½ points, with both the Over and Under priced at -110.
San Francisco enters as the slight favorite thanks to home-field advantage, but Denver remains a dangerous underdog capable of keeping this matchup close. A field-goal spread indicates oddsmakers expect a competitive battle between two talented defenses, while the total of 44½ points suggests a more controlled scoring environment where turnovers, field position, and efficiency in key moments could decide the outcome.
- Game: Sunday, October 4, 2026 at 8:20 PM ET
- Spread: 49ers -3 (-110) / Broncos +3 (-110)
- Total: 44½ (-110 both sides)