This is a tricky game to play. Yes, it figures the NFL betting total line of 49½ points will see the teams soar past that number.
However, Baker Mayfield and the Bucs are getting 5½ points from the Bills. Both teams are coming off losses to AFC East teams, the Bucs to New England and the Bills to Miami.
Offenses should have a big game, and the contest is too unpredictable when it comes to the actual result. Go with the total line.