An NFC West rivalry takes center stage in NFL Week 3 as the Arizona Cardinals travel to Levi’s Stadium to face the San Francisco 49ers. NFL odds have the 49ers as 11½-point home favorites at -11½ (-110), while the Cardinals are +11½ (-110) on the road. The total is set at 46½ points, with both the Over and Under priced at -110.
San Francisco enters the matchup as one of the biggest favorites on the Week 3 board, reflecting the market’s confidence in the 49ers at home. Arizona will look to keep the game competitive and capitalize as a double-digit underdog in what is always a hard-fought divisional battle. Meanwhile, the total of 46½ points suggests expectations for a balanced scoring pace, with enough offensive opportunities to make every possession meaningful.
Game: Sunday, September 27, 2026 at 4:05 PM ET
Spread: 49ers -11½ (-110) / Cardinals +11½ (-110)
Total: 46½ (-110 both sides)