An intriguing NFC matchup headlines the NFL Week 4 schedule as the Arizona Cardinals travel to MetLife Stadium to face the New York Giants. NFL odds have the Giants as 7-point home favorites at -7 (-110), while the Cardinals are +7 (-110) on the road. The total is set at 46½ points, with both the Over and Under priced at -110.
With the spread sitting below a field goal, oddsmakers expect a closely contested matchup between two teams looking to build momentum early in the season. New York gets a slight edge thanks to home-field advantage, while Arizona enters as a live underdog capable of pulling off the outright upset. The total of 45½ points points toward a balanced scoring environment where key turnovers and red-zone efficiency could determine the outcome.
- Game: Sunday, October 4, 2026 at 1:00 PM ET
- Spread: Giants -7 (-110) / Cardinals +7 (-110)
- Total: 45½ (-110 both sides)