An exciting interconference matchup takes place in NFL Week 4 as the Los Angeles Chargers travel to Lumen Field to face the Seattle Seahawks. NFL odds have the Seahawks as 2½-point home favorites at -2½ (-110), while the Chargers are +2½ (-110) on the road. The total is set at 45½ points, with both the Over and Under priced at -110.
A spread of just 2½ points indicates oddsmakers expect a competitive matchup between two talented rosters. Seattle receives the slight advantage thanks to home-field advantage, but Los Angeles remains a strong underdog option with the ability to win outright. The total of 45½ points suggests expectations for an offensive battle, with both teams expected to create scoring opportunities in a matchup where late-game execution could be the deciding factor.
- Game: Sunday, October 4, 2026 at 4:05 PM ET
- Spread: Seahawks -2½ (-110) / Chargers +2½ (-110)
- Total: 45½ (-110 both sides)