Thursday Night Football kicks off NFL Week 4 with an intriguing interconference matchup as the Indianapolis Colts travel to the nation’s capital to take on the Washington Commanders. NFL odds have the Commanders as 4-point home favorites at -4 (-110), while the Colts are +4 (-110) on the road. The total is set at 47½ points, with both the Over and Under priced at -110.
A spread of four points suggests Washington enters the matchup with a clear edge, largely thanks to home-field advantage, but Indianapolis remains within striking distance as a live underdog capable of keeping the contest close. Meanwhile, the total of 47½ points points toward a balanced offensive matchup, with both teams expected to generate scoring opportunities in what could be a competitive way to open the Week 4 slate.
- Game: Thursday, October 1, 2026 at 8:15 PM ET
- Spread: Commanders -4 (-110) / Colts +4 (-110)
- Total: 47½ (-110 both sides)