From the London game on Sunday morning to Bills at Rams on Monday night, the Week 5 NFL odds put every matchup in one place. Compare spreads, moneylines, and totals, explore popular NFL betting markets for the 2026/27 season, and get quick answers in our FAQs.
What Are the Most Popular NFL Bet Types?
Betting on NFL odds means wagering on the sportsbook’s numerical assessment of how likely each game outcome is. Those numbers usually appear in three bet types, plus live betting:
- NFL Spread: The spread handicaps the stronger team so both sides carry roughly equal betting appeal. The favorite is marked with a minus sign, the underdog with a plus. A team at -7 must win by eight or more points to cover; the underdog at +7 covers by winning outright or losing by six or fewer. Pay attention to whether the number is whole or has a half point attached. At a flat -7, a seven-point win is a push and all stakes are returned; at -7½ there is no push and every result settles. Three and seven are the most common winning margins in football, so a line sitting exactly on either carries real push probability — which is why the half point between 3 and 3½ is worth more than it looks.
- NFL Moneyline: The moneyline prices a straight-up winner and ignores the margin entirely. A favorite carries a minus number: at -150 you stake $150 to win $100 in profit. An underdog carries a plus number: at +200 a $100 stake returns $200 in profit, plus your original $100 back. The bigger the gap between the two prices, the more one-sided the market considers the game — a matchup priced -110 either way is close to a coin flip, while -600 against +425 signals a heavy mismatch. You can convert any price into an implied probability: for a minus number, divide it by itself plus 100 (-150 becomes 150 ÷ 250, or 60%); for a plus number, divide 100 by the number plus 100 (+200 becomes 100 ÷ 300, or 33%). Moneylines aren’t always posted on every game, particularly when a line sits at or near a pick’em, in which case the spread is the only way to back a side.
- NFL Totals (over/under): The total is a line set for the combined points both teams are expected to score, and you wager on whether the final figure lands above or below it, regardless of who wins. If the total is 45½, a 24-21 finish combines for 45 points and lands under; a 24-24 finish combines for 48 and lands over. Check the number rather than the winner, which is the habit that trips up newer bettors. As with spreads, half points guarantee a result while whole numbers can push — a total of exactly 45 refunds both sides if the teams combine for 45. Totals also come with implied team totals, which split the number between the two sides and let you bet on one team’s scoring without taking a view on the outcome.
- NFL Live Betting: Live betting means wagering on a game already in progress, with prices redrawn continuously as the score, time remaining, field position, and possession change. A team that opened as a 3-point favorite might be laying 10 after scoring twice in the first quarter, and totals move the same way: a scoreless first quarter pulls the number down, a shootout pushes it up. Markets are briefly suspended after big moments like a scoring play, turnover, or review, so a bet may not be accepted at the price you saw. Live prices also carry a wider margin than pre-game lines and move fast, so by the time you react to what you just watched, the market has usually adjusted. Live betting rewards having decided in advance what you’re waiting for.
How Do You Get Started Betting on the NFL at BetUS?
After logging into your BetUS Sportsbook account, you will see your virtual bet slip. Next, navigate to or search for your favorite team or game, whether it’s the New York Giants or another team. Find the line you want to wager on and select it to add it to your bet slip. Enter the bet amount and submit your single-game wager. To create a parlay, if-bet, teaser, round-robin, or other exotic bet types, add more wagers to your bet slip to unlock advanced betting services. You can find props, half-time lines, and such by selecting the (+ Markets Number) option for the game in question.
By staying informed, betting responsibly, and choosing the right strategies, you can enhance your NFL regular season betting experience and increase your chances of calling the right plays and potentially winning and avoiding losses.
What Other Types of NFL Odds Can You Bet On?
What Are NFL Futures Odds?
NFL futures odds offer a unique way to predict the outcome of the entire season, allowing you to place season-long bets on a variety of markets, including Super Bowl odds.
At BetUS, you can explore a range of options, from predicting Super Bowl odds and divisional champions to conference winners, estimating win totals, and betting on which teams will make or miss the playoffs. Whether you’re looking at the AFC East, the NFC West, or broader conference outcomes. The odds lock at the price taken, and later movement does not change the payout. NFL futures odds provide the widest array of betting options. Learn how to bet on NFL futures odds here.
What Are NFL Player Props and Awards Odds?
BetUS also offers the option of betting on the performances of your favorite players, including most INTs, most passing yards, most receiving yards, most TDs, and much more.
Other top betting markets include MVP, Coach of the Year, Rookie of the Year, and even which coach will be fired first.
What Is NFL Novelty Betting?
NFL novelty betting lets you wager on outcomes beyond the final score by letting bettors wager on unconventional outcomes. Novelty bets include winner props (MVP, coin toss), in-game quirks, and entertainment-focused lines such as Super Bowl halftime show betting—predicting performers, song choices, or guest appearances.
Season-long and player-specific markets cover achievements and pop-culture tie-ins, including speculative scenarios tied to Madden 27 cover odds for emerging stars. Novelty options give casual fans and serious bettors fresh, fun ways to interact with NFL odds.
Why Choose BetUS for NFL Betting?
New to NFL betting? Don’t worry – BetUS has you covered. Our platform is designed to be intuitive for both seasoned bettors and newcomers alike. Plus, we offer attractive welcome bonuses and promotions specifically tailored for the NFL, giving you extra value as you kick off your betting season.
At BetUS, we’re committed to providing a safe and secure betting environment. Our state-of-the-art encryption technology protects your personal and financial information, allowing you to focus on what really matters – enjoying the games and potentially winning big. With BetUS, every play is a potential payday.
Remember, betting should be done responsibly. If you or someone you know has a gambling problem, please call 1-800-GAMBLER for help.
