New York Giants Week 2 vs Los Angeles Rams Week 2

Mon, Sep 21, 2026 | 8:15P EST
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New York Giants Week 2
Los Angeles Rams Week 2
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New York Giants at Los Angeles Rams Odds and Lines

Los Angeles closes out Week 2 on Monday night as a near-double-digit home favorite against New York, with NFL odds placing the Rams at -9½ and the Giants getting the points at +9½, both at standard -110 pricing. Being favored by nearly 10 reflects the market viewing Los Angeles as clearly the stronger roster, with New York cast as a sizable underdog in the primetime finale to the week.
A spread of 9½ sits just outside two-score territory — the Giants would need to either win outright or keep the margin within a touchdown-plus-field-goal to cover, a substantial cushion for backers of the road underdog. The total of 47½ at -110 both sides lands on the higher end for Week 2, pointing to an expectation that the Rams’ offense will contribute meaningfully to the scoring under the lights rather than this shaping up as a defensive grind despite the lopsided spread.

  • Game: Monday, September 21, 2026 at 8:15 PM ET
  • Spread: Rams -9½ (-110) / Giants +9½ (-110)
  • Total: 47½ (-110 both sides)

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