An NFC matchup takes the spotlight in NFL Week 4 as the Detroit Lions travel to Bank of America Stadium to face the Carolina Panthers. NFL odds have the Lions as 3-point road favorites at -3 (-110), while the Panthers are +3 (-110) at home. The total is set at 48½ points, with both the Over and Under priced at -110.
Detroit enters as a clear favorite on the road, reflecting confidence in the Lions’ offensive firepower and ability to control the matchup. Carolina will look to take advantage of home-field advantage and keep the game competitive as a touchdown underdog. The total of 48½ points suggests expectations for an entertaining offensive battle, with both teams expected to create scoring opportunities in a matchup where execution in key moments could decide the final result.
- Game: Sunday, October 4, 2026 at 1:00 PM ET
- Spread: Lions -3 (-110) / Panthers +3 (-110)
- Total: 48½ (-110 both sides)