An AFC East rivalry takes center stage in NFL Week 4 as the New England Patriots travel to Orchard Park to face the Buffalo Bills. NFL odds have the Bills as 3-point home favorites at -3 (-110), while the Patriots are +3 (-110) on the road. The total is set at 49½ points, with both the Over and Under priced at -110.
Buffalo enters the matchup as a sizeable favorite, reflecting the market’s confidence in the Bills at home against a familiar division rival. New England, however, has an opportunity to stay within the number as a live underdog if it can limit Buffalo’s explosive offense. The total of 46½ points suggests a balanced scoring outlook, with the Bills expected to dictate the pace while the Patriots look to capitalize on key opportunities to keep the game competitive.
- Game: Sunday, October 4, 2026 at 1:00 PM ET
- Spread: Bills -3 (-110) / Patriots +3 (-110)
- Total: 49½ (-110 both sides)