Week 12 features an NFC West divisional matchup as the Seattle Seahawks travel to Santa Clara to face the San Francisco 49ers. NFL odds have the 49ers as -1½ point home favorites at -1½ (Even), while the Seahawks are listed as +1½ (-120) as the road underdog.
The total of 46½ points suggests balanced scoring expectations for this divisional showdown. San Francisco must win by at least two points to cover the spread, while Seattle can cover by winning outright or losing by one point. With a narrow spread separating two NFC West rivals, this matchup shapes up as an intriguing betting option for NFL bettors looking at the spread, moneyline and total.
- Game: Sunday, November 29, 2026 at 3:25 PM ET
- Spread: 49ers -1½ (Even) / Seahawks +1½ (-120)
- Total: Over 46½ (-110) / Under 46½ (-110)