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Memphis vs Louisville Odds - College Basketball Lines - Saturday, Dec 13, 2025

Memphis at Louisville Betting Analysis

Years and years ago, this would have been a powerhouse matchup. Times have changed, and Memphis is a roller coaster from season to season.

Louisville was dynamic, but now, it is trying to rebuild after a disastrous run. The Tigers are only 4-4 but have won three in a row.

The best win was in the last game against Baylor. On Saturday, the Tigers will face the Cardinals, who are 8-1 and 6-0 at home. That tilts college basketball week 7 odds toward Louisville in a big way. The Cardinals’ lone loss came at Arkansas.

This should be their seventh win at home in the 2025-26 season. Guard Ryan Conwell leads the attack at 19.7 ppg.

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