Chiefs Installed as Slim Home Favorites in Super Bowl Rematch
This Week 16 matchup sees NFL odds installing Kansas City as a 2.5-point favorite over San Francisco. The Chiefs are favored at home, with the 49ers sitting at +2.5 (-120) on the spread as they visit Arrowhead Stadium. The 2.5-point line signals oddsmakers expect a closely contested affair, with home-field advantage providing a slight edge for Kansas City.
The total is set at 46.5 points, pointing toward a moderate scoring environment rather than a shootout. With the Chiefs laying just over a field goal and the total settling in the mid-40s, bettors have multiple angles to consider in this Sunday afternoon Super Bowl rematch. Head to BetUS to lock in your wagers before the lines shift.
- Game: Sunday, December 27, 2026 at 4:25 PM ET
- Spread: Chiefs -2.5 (-110) / 49ers +2.5 (-120)
- Total: 46.5 (-110)