Week 12 wraps up the Thanksgiving Day slate with a marquee AFC showdown as the Kansas City Chiefs travel to Buffalo to face the Bills. NFL odds have the Bills as -2½ points home favorites at -2½ (-110), while the Chiefs are listed as +2½ (-110) as the road underdog.
The total of 49½ points signals expectations for one of the highest-scoring games of the Week 12 schedule. Buffalo must win by at least three points to cover the spread, while Kansas City can cover by winning outright or losing by two points or fewer. With two AFC powerhouses meeting in a potential playoff preview, this matchup shapes up as an intriguing betting option for NFL bettors looking at the spread, moneyline and total.
- Game: Thursday, November 26, 2026 at 7:20 PM ET
- Spread: Bills -2½ (-110) / Chiefs +2½ (-110)
- Total: Over 49½ (-110) / Under 49½ (-110)