NFL Week 12 (2025) — Key Matchups to Watch and Betting Angles
Monday Night Football:
Carolina Panthers @ San Francisco 49ers
Mon., Nov 24 — 8:15 p.m. ET (ESPN)
- Opening NFL odds: 49ers -7.5 on the spread, -365 ML; Panthers +293; total 49.5 points.
- San Francisco supporters who dislike the juice can opt for an alternative spread (–9.5) at plus odds or anchor the ML in a two-team teaser with the under.
- Panthers backers can grab +7.5 or tease Carolina up to +13, pairing the dog spread with the under for a bigger payout.
- Sack props on Nick Bosa and Bryce Young’s passing-yard ladders headline the prop board; NFC West futures will swing if the Niners slip.
Bye week: Denver Broncos, Los Angeles Chargers, Miami Dolphins, Washington Commanders
NFL Week 12 Schedule & How To Watch
Thursday, November 20th, 2025
- Buffalo Bills at Houston Texans – 8:15 p.m. – Prime Video
Sunday, November 23rd, 2025
- New England Patriots at Cincinnati Bengals – 1:00 p.m. – CBS / Paramount+
- Pittsburgh Steelers at Chicago Bears – 1:00 p.m. – CBS / Paramount+
- Indianapolis Colts at Kansas City Chiefs – 1:00 p.m. – CBS / Paramount+
- New York Jets at Baltimore Ravens – 1:00 p.m. – CBS / Paramount+
- New York Giants at Detroit Lions – 1:00 p.m. – FOX / Fox Sports app
- Seattle Seahawks at Tennessee Titans – 1:00 p.m. – FOX / Fox Sports app
- Minnesota Vikings at Green Bay Packers – 1:00 p.m. – FOX / Fox Sports app
- Cleveland Browns at Las Vegas Raiders – 4:05 p.m. – CBS / Paramount+
- Jacksonville Jaguars at Arizona Cardinals – 4:05 p.m. – CBS / Paramount+
- Atlanta Falcons at New Orleans Saints – 4:25 p.m. – FOX / Fox Sports app
- Philadelphia Eagles at Dallas Cowboys – 4:25 p.m. – FOX / Fox Sports app
Sunday Night
- Tampa Bay Buccaneers at Los Angeles Rams – 8:20 p.m. – NBC / Peacock
Monday, November 24th, 2025
- Carolina Panthers at San Francisco 49ers – 8:15 p.m. – ESPN (MNF)
How to watch NFL Week 12 2025
Thursday Night Football: Exclusive on Prime Video. A Prime membership (or standalone TNF plan) is required.
Sunday Afternoon
- CBS games stream locally on Paramount+.
- FOX games stream free with a pay-TV login in the Fox Sports app (and are expected on the upcoming Fox One service).
- Sunday Night Football: Broadcast on NBC and streams nationwide on Peacock.
- Monday Night Football: Airs on ESPN; also available in the ESPN app for authenticated subscribers.
- Cord-cutting bundles: YouTube TV, Fubo, Hulu + Live TV, and DirecTV Stream carry CBS, FOX, NBC, and ESPN, ensuring access to every Week 12 telecast.
- NFL+: Offers live local and prime-time games on mobile, plus NFL RedZone for Sunday-afternoon whip-around coverage.
