College Football Week 4 Odds: Rivalries, Spreads & Showdowns Await
The honeymoon phase is over. College Football Week 4 is where things get real. Non-conference tune-ups are in the rearview, and now the games carry weight. Conference title dreams, playoff resumes, and coaching reputations are all on the line. Every snap matters more. Every mistake hurts more. And every bet comes with a little extra juice.
So what’s on tap? A slate stacked with ranked clashes, historic rivalries, and spreads so wide you’ll wonder if the oddsmakers are daring you to jump. Whether you’re hunting value in a one-score battle or chasing a blowout cover, BetUS has you covered.
Join BetUS & Bet Now to lock in spreads, moneylines, totals, alternate lines, first-half odds, and game props. Don’t forget to check out this week’s NFL betting slate.
Marquee Week 4 Matchups to Watch
Week 4 is the first true stress test. Teams that looked sharp in September finally get punched back. Some will fold. Some will announce themselves as legit contenders. That’s where the betting value lives.
This week’s slate features:
- Ranked-on-ranked violence: Matchups where playoff hopefuls can’t afford a slip. Top-10 squads taking on desperate underdogs fighting to stay relevant. These are the lines that shift fast, so keep an eye out.
- Rivalry showdowns: State bragging rights mean everything. Teams circle these games months in advance. Form doesn’t matter. Records don’t matter. Sometimes the number on the spread doesn’t matter either. That’s the beauty of betting rivalries.
- Monster spreads: Favorites laying 30, 40, even 45 points. Will they keep starters in long enough to cover? Or will the backups ruin your ticket? Bettors love these spots because the margin for error is razor-thin.
The big picture: Week 4 separates contenders from pretenders. And that makes for sharper lines, higher stakes, and betting opportunities you won’t see in the sleepy weeks of September.
College Football Opening Odds for Week 4 Notable Games
- No. 17 Texas Tech at No. 16 Utah (-3.5) (Noon ET, Fox)
- UAB at No. 15 Tennessee (-38.5) (12:45 p.m. ET, SEC Network)
- Oregon State at No. 6 Oregon (-35.5) (3 p.m. ET, BTN)
- Kent State at No. 7 Florida State (-43.5) (3:30 p.m. ET, ACC Network)
- No. 22 Auburn at No. 11 Oklahoma (-6.5) (3:30 p.m. ET, ABC)
- Tulane at No. 13 Ole Miss (-12.5) (3:30 p.m. ET, ESPN)
- No. 21 Michigan (-1.5) at Nebraska (3:30 p.m. ET, CBS)
- Purdue at No. 24 Notre Dame (-28.5) (3:30 p.m. ET, NBC)
- Temple at No. 18 Georgia Tech (-23.5) (4:30 p.m. ET, CW)
- South Carolina at No. 23 Missouri (-13.5) (7 p.m. ET, ESPN)
- Florida at No. 4 Miami (-7.5) (7:30 p.m. ET, ABC)
- No. 9 Illinois at No. 19 Indiana (-4.5) (7:30 p.m. ET, NBC)
- Georgia State at No. 20 Vanderbilt (-26.5) (7:30 p.m. ET, ESPNU)
- SE Louisiana at No. 3 LSU (7:45 p.m. ET, SEC Network)
- Sam Houston at No. 8 Texas (-41.5) (8 p.m. ET, ESPN+)
- Michigan State at No. 25 USC (-15.5) (11 p.m. ET, Fox)
odds subject to change
How to Bet Week 4 at BetUS
BetUS isn’t just about spreads and moneylines. Sure, you can grab those in seconds. But Week 4 is built for deeper plays. That’s where alternate lines, halves, and props shine.
Want to shorten a favorite from -12.5 to -6.5 for a safer sweat? Hit the alternate line market. Think a shootout starts hot but fizzles late? First-half totals are your friend. Chasing a specific star to hit 100 yards? Player props let you target individual matchups without sweating the scoreboard.
Everything is built mobile-first. Whether you’re on iOS, Android, or your laptop, the BetUS board updates live. That means sharper odds, faster access, and more ways to get action on Week 4.
Betting Markets Explained
Think you know who will win? There are countless ways to bet on the game. Master these markets to find the best value in the college football Week 4 odds.
- The Spread: The Point Spread Is the Great Equalizer in Football Betting. The favorite must win by more than the spread number. The underdog can win outright or lose by less than the number to cover. For example, if Alabama is -14.5, they need to win by 15 or more points. Simple, right?
- The Moneyline Forget the points. The NCAAF Week 4 moneyline is about one thing: picking the winner. The favorite will have minus odds (like -200), meaning you risk more to win less. The underdog has plus odds (+180), offering a bigger payout for the upset. Bet on who you think wins the game straight up.
- Totals (Over/Under) This isn’t about who wins. It’s about how many points are scored. We set a total number for the combined score of both teams. You bet on whether the final score will be Over or Under that number. Check the college football totals if you expect a shootout or a defensive slugfest.
- Props and Alternate Lines This is where you can really find an edge. Don’t like the main line? Check out the alternate college football spreads. Want to bet on a specific player? Bet on college football props for passing yards, rushing touchdowns, and more. Game props let you bet on everything from the first team to score to individual quarter results.
