Welcome to November. This is where the contenders are separated from the pretenders, and the playoff picture finally gets clear. Week 10 is a gauntlet of season-defining games, and every point spread matters. Your search for the sharpest College Football Week 10 Odds ends right here. BetUS has the complete board, from the big-time Big Ten clash to the SEC eliminators.
College Football Week 10 Betting Odds: Top Games & Betting Markets
This page is your mission control. Below the odds, you’ll find our expert breakdown of why the lines are what they are—no fluff, just analysis. We’ll dive into the marquee matchups, explain how to attack the CFB Week 10 Spreads, and show you how to leverage player props. It’s time to build your bet slip.
Week 10 Marquee Matchups: What to Watch
#1 Ohio State vs. Penn State: A Big Ten Collision
The Buckeyes put their undefeated record and #1 ranking on the line in one of their toughest remaining tests. This game is a classic clash of styles, pitting Ohio State’s high-powered offense against a historically stingy Penn State defense. For bettors, the CFB Week 10 Spreads (-20.5 for OSU) will be a focal point, as will CFB player props for the star wide receivers on the field. The game’s pace will heavily influence the College Football Totals.
#9 Vanderbilt at #20 Texas: A New-Look SEC Showdown
Vanderbilt’s historic 7-1 start meets a Texas team fighting to stay in the conference title race. The key storyline here is the health of Texas QB Arch Manning, an injury that will directly impact the NCAAF Moneylines and spread all week. This is a “prove it” game for the Commodores, and the betting lines (Texas -3) will reflect whether the market believes their Cinderella run is for real, especially on the road.
#18 Oklahoma at #14 Tennessee: SEC Playoff Eliminator
Two conference powers collide in what is essentially a playoff elimination game. Both teams boast high-octane offenses, making the game total (Over/Under) a primary market of interest. This matchup is also a prime candidate for the best CFB player props this week, with Heisman-hopeful quarterbacks on both sides. The line movement on the -3.5 spread will be driven by which defense is trusted to get even one or two critical stops.
#5 Georgia vs. Florida: The World’s Largest Outdoor Cocktail Party
Throw the records out. This is one of the sport’s most intense rivalries, and the neutral-site location in Jacksonville adds a unique variable. The NCAAF Moneylines and CFB Week 10 Spreads (Georgia -7.5) in rivalry games are often tighter, driven by emotion as much as stats. Look for game props like “First Team to Score” or “Team Total Points” as popular ways to bet on college football and the game’s momentum swings.
#17 Cincinnati at #24 Utah: Late-Night Power Clash
This late-night battle is a massive game for conference positioning, with Utah sitting as a 7-point home favorite. The Utes’ tough defense at home versus Cincinnati’s explosive offense will be the key matchup. The NCAAF Week 10 Lines here will be all about travel and home-field advantage in that tough Salt Lake City environment.
What are Week 10’s top featured and notable games?
Friday, October 31
- No. 25 Memphis (-14) at Rice (7 p.m. ET, ESPN2)
Saturday, November 1
- Penn State at No. 1 Ohio State (-20.5) (Noon ET, Fox)
- No. 9 Vanderbilt at No. 20 Texas (-3) (Noon ET, ABC)
- No. 10 Miami (-10) at SMU (Noon ET, ESPN)
- West Virginia at No. 22 Houston (-14.5) (Noon ET, FS1)
- No. 16 Louisville (-10) at Virginia Tech (3 p.m. ET, CW)
- No. 2 Indiana (-21.5) at Maryland (3:30 p.m. ET, CBS)
- No. 5 Georgia (-7.5) vs. Florida (3:30 p.m. ET, ABC)
- No. 12 Notre Dame (-28.5) at Boston College (3:30 p.m. ET, ESPN)
- No. 13 Texas Tech (-7) at Kansas State (3:30 p.m. ET, Fox)
- No. 15 Virginia (-4.5) at California (3:45 p.m. ET, ESPN2)
- South Carolina at No. 7 Ole Miss (-13.5) (7 p.m. ET, ESPN)
- Purdue at No. 21 Michigan (-21) (7 p.m. ET, BTN)
- No. 8 Georgia Tech (-6.5) at NC State (7:30 p.m. ET, ESPN2)
- No. 18 Oklahoma at No. 14 Tennessee (-3.5) (7:30 p.m. ET, ABC)
- No. 23 USC (-6) at Nebraska (7:30 p.m. ET, NBC)
- No. 17 Cincinnati at No. 24 Utah (-7) (10:15 p.m. ET, ESPN)
How to Bet the College Football Week 10 Odds
Mastering the Point Spread
The point spread is the great equalizer. It’s the most popular way to bet on college football. If you bet on #1 Ohio State -20.5, they must win by 21 or more points for your bet to cash. If you take Penn State +20.5, they can win the game or lose by 20 or fewer. This is the top way to bet on games with a clear favorite and underdog, like #12 Notre Dame laying -28.5 at Boston College.
The Moneyline: Picking the Outright Winner
The moneyline is simple: just pick the winner. For example, in the Vanderbilt vs. Texas game, the moneyline odds will be different for each side. A bet on the underdog Commodores at +125 would pay $125 on a $100 wager. A bet on the favorite Longhorns at -145 would require a $145 wager to win $100. This is where you find value on underdogs you think can win outright.
Totals (Over/Under): Betting on Game Flow
Don’t care who wins? Bet the total. In the Oklahoma vs. Tennessee matchup, the College Football Totals might be set at 68.5 points. If you bet the Over, you’re rooting for a 38-35 shootout. If you bet the Under, you’re banking on a 31-28 defensive battle. This is a bet on the game’s overall pace and offensive efficiency.
Beyond the Basics: Unlocking Props and Alternate Lines
Game Props & Player Props: Bet on the Story
This is where you can bet on the game within the game.
- Player Props: Wager on an individual’s performance. For example: “Ohio State QB Passing Yards: Over/Under 305.5” or “Tennessee RB: Anytime Touchdown Scorer.” These are some of the best CFB player props this week.
- Game Props: Bet on team or game outcomes. For example: “Team to Score First: Georgia” or “Will the game go to Overtime: Yes/No.” Our BetUS sportsbook has a huge menu for every game.
Alternate Lines: Create Your Own Spread
Don’t like the main line? Change it. If you think Penn State +20.5 isn’t enough, you can use the alternate lines to “buy” points and get them at +24.5 (for a lower payout). Conversely, if you think Georgia (-7.5) will win in a blowout, you can “sell” points and bet them at -10.5 for a much larger potential return. This tool gives you full control over your wager’s risk and reward. This is how to bet on college football alternate lines.
