Must-Watch Games — NFL Week 16 (2025) & Betting Angles
Early Sunday :
Kansas City Chiefs @ Tennessee Titans
Sun., Dec 21 – 1:00 p.m. ET – CBS/Paramount+
- Opening NFL odds post Kansas City as a 4-point chalk on the point spread with a –205 moneyline; the total sits near 48.
- Chiefs backers who dislike the juice can pivot to an alternate spread (–6.5) at plus money or drop K.C. into a six-point teaser with another favorite.
- Titans believers may grab the +4 head-start or sprinkle a +170 underdog moneyline, banking on Derrick Henry’s dome-turf burst.
- Result implications: a KC win (plus a Raiders loss) clinches the AFC West, while Tennessee needs the upset to stay in the South race.
Late Sunday Window:
Pittsburgh Steelers @ Detroit Lions
4:25 p.m. – CBS
- Detroit opens –5.5 on the spread and –230 on the ML.
- Steelers backers can tease Pittsburgh up to +11.5 or target a T.J. Watt sack prop at plus odds.
- Lions supporters chasing value might shift to an alternate line (–8.5) at a bigger payday.
Sunday Night Football:
Cincinnati Bengals @ Miami Dolphins
Sun., Dec 21 – 8:20 p.m. ET – NBC/Peacock
- Consensus NFL odds call this a near pick’em (Miami –1) with Week 16’s highest total at 51.
- Bengals believers can tease Joe Burrow up to +7 or attack an alternate spread (–3.5) at a juicy price if they trust Cincy’s road form.
- Dolphins backers wary of the hook might buy down to –0.5 or pair the –115 moneyline with the over in a same-game parlay.
- Expect “yardage ladder” props on Ja’Marr Chase and Tyreek Hill to move quickly; the winner likely exits as the AFC’s No. 2 seed.
Monday Night Football:
San Francisco 49ers @ Indianapolis Colts
Mon., Dec 22 – 8:15 p.m. ET – ESPN/ABC
- Opening NFL betting lines make San Francisco a 6-point road favorite (–6) with a –240 moneyline and a 46-point total.
- 49ers bettors who hate the juice can target an alternate spread (–9.5) at plus money or anchor the ML in a two-team teaser with the under.
- Colts supporters can tease Indy up to +12 or sprinkle the +200 upset, noting their 6-1 ATS mark as a home dog since 2024.
- Prop spotlight: Nick Bosa sack total, Anthony Richardson rushing-yard ladders, and first-TD markets—all expected to drive the Monday-night handle.
Bye Week: None (all 32 teams play).
NFL Week 16 Schedule & How To Watch
Thursday, December 18th, 2025
- Los Angeles Rams at Seattle Seahawks – 8:15 p.m.- Prime Video
Saturday, December 20th, 2025 (*Saturday kickoff times were assigned as part of FOX’s Week 16 double-header)
- Green Bay Packers at Chicago Bears* – 4:30 p.m. – FOX / NFL+
- Philadelphia Eagles at Washington Commanders* – 8:00 p.m. – FOX / NFL+
Sunday, December 21st, 2025 — Early Window
- Kansas City Chiefs at Tennessee Titans – 1:00 p.m. – CBS / Paramount+
- New York Jets at New Orleans Saints – 1:00 p.m. – CBS / Paramount+
- New England Patriots at Baltimore Ravens – 1:00 p.m. – CBS / Paramount+
- Buffalo Bills at Cleveland Browns – 1:00 p.m. – CBS / Paramount+
- Tampa Bay Buccaneers at Carolina Panthers – 1:00 p.m. – FOX
- Minnesota Vikings at New York Giants – 1:00 p.m. – FOX
- Los Angeles Chargers at Dallas Cowboys – 1:00 p.m. – FOX
Sunday — Late Window
- Atlanta Falcons at Arizona Cardinals – 4:05 p.m. – FOX
- Jacksonville Jaguars at Denver Broncos – 4:05 p.m. – FOX
- Pittsburgh Steelers at Detroit Lions – 4:25 p.m. – CBS
- Las Vegas Raiders at Houston Texans – 4:25 p.m. – CBS
Sunday Night Football
- Cincinnati Bengals at Miami Dolphins – 8:20 p.m. – NBC & Peacock
Monday, December 22nd, 2025
- San Francisco 49ers at Indianapolis Colts – 8:15 p.m. – ESPN / ABC simulcast
How to Watch NFL Week 16, 2025
- Prime Video: Exclusive home for Thursday Night Football.
- Saturday Double-Header (FOX): Both games also stream in the Fox Sports app with a pay-TV login; in-market mobile viewing available on NFL+.
Sunday Afternoon:
- CBS games stream locally on Paramount+.
- FOX games stream in the Fox Sports app and, where available, on the upcoming Fox One service.
- Sunday Night Football: Broadcast on NBC and streams nationwide on Peacock.
- Monday Night Football: Simulcast on ESPN and ABC; both streams available in the ESPN app.
- Cord-cutters: YouTube TV, Fubo, Hulu + Live TV, and DirecTV Stream carry CBS, FOX, NBC, ABC, and ESPN, covering every Week 16 telecast.
- NFL+: Offers live local and prime-time games on mobile, plus NFL RedZone for whip-around Sunday coverage.
