Week 9 features an AFC vs. NFC matchup as the Las Vegas Raiders travel to the Bay Area to face the San Francisco 49ers. NFL odds have the 49ers as -8½ points home favorites at -8½ (-110), while the Raiders get the points at +8½ (-110) as the road underdog.
The total of 46½ points suggests a matchup with balanced scoring expectations, while the sizable spread indicates San Francisco enters as the clear favorite. Las Vegas will look to keep the game within one possession, while the 49ers aim to protect home field and cover the number. The combination of a moderate total and a larger spread makes this one an intriguing betting option for NFL bettors looking at the spread, moneyline and total.
- Game: Sunday, November 8, 2026 at 3:05 PM ET
- Spread: 49ers -8½ (-110) / Raiders +8½ (-110)
- Total: Over 46½ (-110) / Under 46½ (-110)