Los Angeles Chargers Week 3 vs Buffalo Bills Week 3

Sun, Sep 27, 2026 | 1:00P EST
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Los Angeles Chargers Week 3
Buffalo Bills Week 3
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Los Angeles Chargers at Buffalo Bills Odds and Lines

One of the top AFC matchups of NFL Week 3 features the Los Angeles Chargers traveling to Buffalo to take on the Bills in what could have major playoff implications later in the season. NFL odds have the Bills as a 2½-point home favorite at -2½ (-110), while the Chargers are +2½ (-110) on the road. The total is set at 48½ points, with both the Over and Under carrying -110 odds.

A spread of just 2½ points signals that oddsmakers expect a highly competitive contest between two AFC contenders. Buffalo gets the edge thanks to home-field advantage, but the Chargers remain well within striking distance as a live underdog. Meanwhile, the total of 48½ points suggests bettors can expect plenty of offensive production, with both teams capable of generating explosive plays and turning this into one of the highest-scoring games on the Week 3 slate.

  • Game: Sunday, September 27, 2026 at 1:00 PM ET
  • Spread: Bills -2½ (-110) / Chargers +2½ (-110)
  • Total: 48½ (-110 both sides)

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