One of the top AFC matchups of NFL Week 3 features the Los Angeles Chargers traveling to Buffalo to take on the Bills in what could have major playoff implications later in the season. NFL odds have the Bills as a 2½-point home favorite at -2½ (-110), while the Chargers are +2½ (-110) on the road. The total is set at 48½ points, with both the Over and Under carrying -110 odds.
A spread of just 2½ points signals that oddsmakers expect a highly competitive contest between two AFC contenders. Buffalo gets the edge thanks to home-field advantage, but the Chargers remain well within striking distance as a live underdog. Meanwhile, the total of 48½ points suggests bettors can expect plenty of offensive production, with both teams capable of generating explosive plays and turning this into one of the highest-scoring games on the Week 3 slate.
- Game: Sunday, September 27, 2026 at 1:00 PM ET
- Spread: Bills -2½ (-110) / Chargers +2½ (-110)
- Total: 48½ (-110 both sides)