An AFC South rivalry takes center stage in NFL Week 3 as the Houston Texans travel to Indianapolis to face the Colts in a matchup that could have early divisional implications. NFL odds have the Texans as 1½-point road favorites at -1½ (-115), while the Colts are +1½ (-105) at home. The total is set at 45½ points, with both the Over and Under priced at -110.
With a spread of just 1½ points, oddsmakers expect a tightly contested battle between two familiar division rivals. Houston enters with a slight edge despite playing on the road, but Indianapolis has an excellent opportunity to pull off the upset in front of its home crowd. The total of 45½ points suggests a balanced offensive matchup, where every possession could prove critical in a game that may come down to the final drive.
- Game: Sunday, September 27, 2026 at 1:00 PM ET
- Spread: Texans -1½ (-115) / Colts +1½ (-105)
- Total: 45½ (-110 both sides)