NFL Week 1 Odds and Betting Lines 2026

The 2026 NFL odds for Week 1 open with one of the most compelling slates in recent memory. Action begins on Wednesday, September 9, with the New England Patriots visiting the Seattle Seahawks, before the 49ers and Rams make history with the league’s first-ever regular-season game played in Australia at the Melbourne Cricket Ground on Thursday, September 10.

The full Sunday card on September 13 delivers wall-to-wall action across all three bet types — spreads, moneylines, and totals — with marquee matchups including Bills vs Texans, Eagles vs Commanders, Lions vs Saints, and the Cowboys vs Giants Sunday Night Football showdown. Monday Night Football on September 14 closes the week with Broncos vs Chiefs at Arrowhead Stadium — one of the most anticipated season-opening matchups on the board.

All 16 NFL Week 1 point spreads, moneylines, and over/under totals are live and updated in real time at BetUS.

NFL Week 1 Point Spreads & Odds — Key Matchups

New England Patriots vs Seattle Seahawks — Season Opener

Wednesday, September 9 · 8:20 PM EST · Lumen Field · NBC/Peacock

The 2026 season opens on a Wednesday night in Seattle, with the Seahawks installed as 3½-point home favorites and the total at 43½ — one of the lower numbers on the Week 1 board. Both sides of the spread are priced at standard -110, so the market gives no directional lean here.

The 3½ is the number to weigh. It sits just above the key number of 3, which means New England covers on a three-point loss rather than pushing — worth something on a road underdog, since one-score losses are the most likely outcome for a team getting less than a touchdown. If the line ticks down to -3 before kickoff, that same result becomes a push and the +3½ loses its edge. On the moneyline, Seattle at -190 and New England at +163 imply roughly a 65/35 split, consistent with a 3½-point spread. With the total at 43½, the market is projecting something close to 24-20 rather than an opening-night shootout.

San Francisco 49ers vs Los Angeles Rams Odds — NFL Australia Game

Thursday, September 10 · 8:35 PM EST · Melbourne Cricket Ground · Netflix

The Rams are the designated home team for the league’s first regular-season game in Australia, but that designation is nominal — no crowd advantage, and both teams travel the same distance. That matters for reading the number. Home field is typically worth around two to two-and-a-half points, so a neutral-site line of -3½ implies the market rates Los Angeles as clearly better on paper rather than simply at home. The 3½ sits above the key number of 3, meaning San Francisco covers on a three-point loss — the most common margin in football. If this moves to -3 before kickoff, that outcome becomes a push instead of a win for 49ers backers, so the half-point is worth monitoring. The 48½ total is the third-highest on the Week 1 board.

Tampa Bay Buccaneers vs Cincinnati Bengals

Sunday, September 13 · 1:00 PM EST · Paycor Stadium · FOX

The total is the headline: 52½, the highest on the entire Week 1 board and fourteen points above the lowest (Jets at Titans, 38½). Cincinnati is a 3½-point home favorite, but the spread is the secondary market here.

A 52½ total implies roughly 28 points for Cincinnati and 24 for Tampa Bay — a projection that demands sustained scoring from both offenses rather than one big quarter. That sets a demanding bar for the over: it takes something like seven combined touchdowns and a field goal to clear. The counter-argument is that Week 1 totals carry more uncertainty than any other week, since the market is pricing off projection rather than a single snap of regular-season evidence. Overs and unders both tend to see sharper movement in the opening week for exactly that reason.

On the spread, the 3½ clears the key number of 3, so Tampa Bay covers on a three-point road loss. Note that Buccaneers/Bengals is priced identically to Patriots/Seahawks — +3½ at +163 against -3½ at -190 — despite a nine-point gap in the totals, a useful reminder that spread and total are set independently.

Buffalo Bills vs Houston Texans Odds — Week 1

Sunday, September 13 · 1:00 PM EST · NRG Stadium · CBS

The tightest spread on the Week 1 board: this game is a pick’em (PK), meaning neither side is favored — Buffalo is priced at -105 and Houston at -115 on the spread, which is functionally a moneyline bet on who wins outright. Because there’s no favorite, there’s no push risk on a specific margin; either team winning by any amount settles the spread. The moneyline pricing mirrors this closely, so bettors backing either side should compare the two markets directly to see which offers the better number on a given day. The 44½ total sits mid-range for Week 1.

New Orleans Saints vs Detroit Lions Odds — Week 1

Sunday, September 13 · 1:00 PM EST · Ford Field · FOX

Detroit is the largest home favorite of the early Sunday window at -7, with the total at 49½ — second-highest on the Week 1 board behind Buccaneers/Bengals at 52½. Together those numbers imply roughly 28 points for Detroit and 21 for New Orleans. The 7 is the second-most common NFL margin after 3, which makes this a push-sensitive line: a Lions win by exactly seven refunds both sides. Bettors who want to avoid that have clean alternatives at either end — Saints +272 needs an outright upset but carries no push risk, while Lions -335 requires a sizeable stake for a one-score win.

Kansas City Chiefs vs Denver Broncos Odds — Monday Night Football

Monday, September 14 · 8:15 PM EST · GEHA Field at Arrowhead Stadium · ESPN/ABC

Patrick Mahomes and the Kansas City Chiefs open Monday Night Football as 3-point favorites over the Denver Broncos at Arrowhead Stadium, with the total set at 42½. The Chiefs are installed at -140 on the moneyline, with Denver available at +120 — a competitive price that reflects what promises to be a tight AFC West rivalry opener. The total of 42½ is one of the lower marks on the Week 1 board, pointing toward a defensively grounded contest between two teams that know each other well. Bettors looking at the Chiefs spread will note the -105 juice on the Kansas City side, making it one of the better-priced favorites of the opening week.

Washington Commanders vs Philadelphia Eagles Odds — Week 1

Sunday, September 13 · 4:25 PM EST · Lincoln Financial Field · FOX

Philadelphia is a 4-point home favorite, and the juice is the detail to read. Washington +4 costs -105 while Philadelphia -4 costs -115 — the book charging more for the favorite than the underdog, which typically means the market’s true number sits closer to 4½ than 3½. The +4 also clears the key number of 3, so Washington covers on a three-point loss and only pushes if it loses by exactly four. On the total, the over is -115 and the under -105, a slight lean toward the under in the pricing.

Dallas Cowboys vs New York Giants Odds — Sunday Night Football

Sunday, September 13 · 8:20 PM EST · MetLife Stadium · NBC/Peacock

This game carries two whole numbers, which is unusual and consequential. Dallas is -3, exactly on the most common NFL margin, so a three-point Cowboys win pushes rather than wins for spread backers. The total is a flat 48 rather than 48½, so a 48-point game refunds both sides there as well. Anyone who dislikes push exposure has alternatives on both markets: Dallas -150 on the moneyline pays on any win, and the Giants at +129 need only a one-point upset. Both sides of the spread are standard -110, so the pricing gives no directional signal — the market reads this as a genuine three-point game.

Denver Broncos vs Kansas City Chiefs — Monday Night Football

Monday, September 14 · 8:15 PM EST · GEHA Field at Arrowhead Stadium · ESPN/ABC

Kansas City closes Week 1 as a 3-point home favorite, and this is the best-priced spread on the board for favorite backers: Chiefs -3 costs just -105, while Broncos +3 costs -115. That’s the reverse of the usual arrangement, and it suggests the market’s true number sits fractionally under 3 — the book is discounting the favorite to attract that side. Sitting exactly on 3 also means a three-point Kansas City win pushes rather than losing for Denver backers. On the moneyline, Kansas City is -145 with Denver at +125. The 42½ total is among the lowest of the week and a full ten points below the board’s ceiling, pointing to a defensive divisional opener rather than a shootout.

What are the favorite types of bets for NFL Week 1?

NFL odds come in a few main categories:

• NFL Spread: One team is the favorite, marked with a minus sign and a number next to its points; the other is the underdog, marked with a plus sign. In the Week 1 opener, for example, the Chargers are -10½ against the Cardinals, meaning Los Angeles must win by 11 or more to cover, while Arizona at +10½ covers by winning outright or losing by 10 or fewer.
• NFL Moneyline: This market uses plus and minus signs to price a straight-up winner. A favorite is listed as a minus number — the Bills at -115 means you’d bet $115 to win $100. An underdog is a plus number — the Texans at -105 in that same game are nearly a coin flip, while a bigger underdog like the Cardinals at +450 means a $100 bet would return $450 if they win.
• NFL Totals (over/under): This is a line set for the combined points both teams are expected to score. In the Bengals-Buccaneers game, the total is 52 — the highest on the Week 1 Sunday slate. Bettors wager on whether the final combined score lands over 52 or under it, regardless of who wins.

What key factors influence the setting of NFL Week 1 odds?

NFL odds Week 1 are influenced by what teams did in the previous season and offseason. While the prior campaign doesn’t always dictate success or failure in the next one, it does provide a barometer for how a team has done.

Add in other factors like coaching changes, free-agent signings, trades, and draft picks, and BetUS and all other sportsbooks have a gauge to make a line. Throw in where the game is played, who is home, and who is away, and the thought process can be completed. NFL Week 1 Odds & Betting Lines are a great chance to find the spot to make plays before the season takes its shape.

NFL Odds Week 2 are determined in a big way by what happens in Week 1. Who wins, who loses, what players thrive, and which ones nosedive.

Additionally, home-field advantage influences the decision on where to set the ATS and moneyline. And depending on how many points were scored by teams in Week 1 games, that could impact the totals for Week 2.

What are other types of bets for NFL Week 1?

As mentioned, common types of bets for NFL Week 1 are ATS, Moneyline, and Totals. There are also numerous options in the prop market, and one can tie wagers together on the same game or different ones by making plays.

An aside to NFL Week 1 bets, are futures. They can be found on BetUS and provide opportunities to bet on teams one thinks will win the Super Bowl.

To cash an NFL Super Bowl odds bet, the team you bet on has to win the NFL championship game. The futures markets fluctuate depending on what happens in the offseason and are adjusted week-to-week based on news and game results.

Why Choose BetUS for NFL Betting

Our user-friendly NFL betting platform makes it a breeze to navigate through all the NFL Week 1 odds. Whether you’re looking to place a spread bet, back your favorite team on the moneyline, or wager on the game total, you’ll find all these options and more just a few clicks away. For those seeking even more excitement, explore our wide range of game props that let you bet on specific player performances, team statistics, and game events.

We pride ourselves on offering up-to-the-minute NFL Week 1 odds that reflect the latest NFL news, injury reports, and team developments. This ensures that you always have access to the most current lines when you’re ready to place your bets. Our mobile-optimized site allows you to check odds and make wagers on the go, so you never miss out on a great betting opportunity.