NFL Week 1 Odds and Betting Lines 2026

The 2026 NFL odds for Week 1 cover all 16 games, with moneylines, spreads, and totals live on every game. The week opened on Wednesday, September 9, when the New England Patriots visited the Seattle Seahawks in a Super Bowl LX rematch, and continued on Thursday with the league’s first regular-season game in Australia as the San Francisco 49ers met the Los Angeles Rams at Melbourne Cricket Ground.

The bulk of the slate runs Sunday, September 13, with early games from 1:00 p.m. ET, late games from 4:25 p.m. ET, and Dallas at the New York Giants on Sunday Night Football. Denver at Kansas City closes the week on Monday night.

Several of the week’s most closely priced games sit on whole numbers, which means a push is live — an exact winning margin or combined score returns your stake. Check whether the line in front of you carries a half point before you bet.

NFL Week 1 Point Spreads & Odds — Key Matchups

Denver Broncos at Kansas City Chiefs — Monday Night Football

Monday, September 14 · 8:15 PM EST · GEHA Field at Arrowhead Stadium · ESPN/ABC

Kansas City closes Week 1 as a 1-point home favorite, down from 3, with the total at 43½. The Chiefs are -135 on the moneyline, Denver +115.

A two-point move during the week is the story here, and at -1 the spread has nearly collapsed into the moneyline. One result separates them: a Kansas City win by exactly one point, which pushes the spread but pays on the moneyline. Everything else resolves the same way on both. That makes price the deciding factor. Chiefs -1 costs -120 against -135 on the moneyline, and all you give up is a one-point win becoming a refund rather than a payout. Denver at +115 pays more than +1 at even money, and forfeits the same refund. The favorite is still the more expensive side of the spread, which points to a true number sitting just above 1 rather than below it.

The total has ticked up to 43½, which removes the push — every combined score now settles one side or the other.

What are the favorite types of bets for NFL Week 1?

NFL odds come in a few main categories:

• NFL Spread: The spread handicaps the stronger team so both sides carry roughly equal betting appeal. The favorite is marked with a minus sign, the underdog with a plus. A team at -7 must win by eight or more points to cover; the underdog at +7 covers by winning outright or losing by six or fewer. Pay attention to whether the number is whole or has a half point attached. At a flat -7, a seven-point win is a push and all stakes are returned; at -7½ there is no push and every result settles. Three and seven are the most common winning margins in football, so a line sitting exactly on either carries real push probability — which is why the half point between 3 and 3½ is worth more than it looks.
• NFL Moneyline: The moneyline prices a straight-up winner and ignores the margin entirely. A favorite carries a minus number: at -150 you stake $150 to win $100 in profit. An underdog carries a plus number: at +200 a $100 stake returns $200 in profit, plus your original $100 back. The bigger the gap between the two prices, the more one-sided the market considers the game — a matchup priced -110 either way is close to a coin flip, while -600 against +425 signals a heavy mismatch. You can convert any price into an implied probability: for a minus number, divide it by itself plus 100 (-150 becomes 150 ÷ 250, or 60%); for a plus number, divide 100 by the number plus 100 (+200 becomes 100 ÷ 300, or 33%). Moneylines aren’t always posted on every game, particularly when a line sits at or near a pick’em, in which case the spread is the only way to back a side.
• NFL Totals (over/under): The total is a line set for the combined points both teams are expected to score, and you wager on whether the final figure lands above or below it, regardless of who wins. If the total is 45½, a 24-21 finish combines for 45 points and lands under; a 24-24 finish combines for 48 and lands over… check that against the number rather than the winner, which is the habit that trips up newer bettors. As with spreads, half points guarantee a result while whole numbers can push — a total of exactly 45 refunds both sides if the teams combine for 45. Totals also come with implied team totals, which split the number between the two sides and let you bet on one team’s scoring without taking a view on the outcome.

What key factors influence NFL Week 1 odds?

NFL odds Week 1 are influenced by what teams did in the previous season and offseason. While the prior campaign doesn’t always dictate success or failure in the next one, it does provide a barometer for how a team has done.

Add in other factors like coaching changes, free-agent signings, trades, and draft picks, and BetUS and all other sportsbooks have a gauge to make a line. Throw in where the game is played, who is home, and who is away, and the thought process can be completed. NFL Week 1 Odds & Betting Lines are a great chance to find the spot to make plays before the season takes shape.

NFL Odds Week 2 are determined in a big way by what happens in Week 1. Who wins, who loses, what players thrive, and which ones nosedive.

Additionally, home-field advantage influences the decision on where to set the ATS and moneyline. And depending on how many points were scored by teams in Week 1 games, that could impact the totals for Week 2.

What are other types of bets for NFL Week 1?

As mentioned, common types of bets for NFL Week 1 are ATS, Moneyline, and Totals. There are also numerous options in the prop market, and one can tie wagers together on the same game or different ones by making plays.

An aside to NFL Week 1 bets, are futures. They can be found on BetUS and provide opportunities to bet on teams one thinks will win the Super Bowl.

To cash an NFL Super Bowl odds bet, the team you bet on has to win the NFL championship game. The futures markets fluctuate depending on what happens in the offseason and are adjusted week-to-week based on news and game results.

Why Choose BetUS for NFL Betting

Our user-friendly NFL betting platform makes it a breeze to navigate through all the NFL Week 1 odds. Whether you’re looking to place a spread bet, back your favorite team on the moneyline, or wager on the game total, you’ll find all these options and more just a few clicks away. For those seeking even more excitement, explore our wide range of game props that let you bet on specific player performances, team statistics, and game events.

We pride ourselves on offering up-to-the-minute NFL Week 1 odds that reflect the latest NFL news, injury reports, and team developments. This ensures that you always have access to the most current lines when you’re ready to place your bets. Our mobile-optimized site allows you to check odds and make wagers on the go, so you never miss out on a great betting opportunity.