NFL Week 1 (2025) — Key Matchups & Betting Angles
International Showcase:
Kansas City Chiefs vs. Los Angeles Chargers (São Paulo) – Fri., Sept 5 — 8:00 p.m. ET (YouTube)
- Neutral-site NFL odds make Kansas City a 3-point favorite with a -155 ML and a 44.5-point total.
- Chargers believers can grab the +3 underdog line or tease L.A. up to +9; Chiefs supporters might lay the field-goal spread or couple K.C.’s ML with the over in a same-game parlay.
- Justin Herbert and Patrick Mahomes prop menus—passing-TD totals, yardage ladders—should draw brisk action and sway AFC West futures.
Early Sunday Spotlight:
Las Vegas Raiders @ New England Patriots – Sun., Sept 7 — 1:00 p.m. ET (CBS)
- Foxborough opens with New England –2.5 (–148 ML) and a 43.5 total.
- Raiders backers can sprinkle the +127 ML or pair Las Vegas +2.5 with the under in a teaser.
- Rookie Drake Maye props—INT totals, rushing yards—could reshape Offensive ROY futures.
Cincinnati Bengals @ Cleveland Browns – Sun., Sept 7 — 1:00 p.m. ET (FOX)
- Joe Burrow’s Bengals lay 5.5 points (–242 ML) on a 45.5 total.
- Browns supporters might chase the +197 upset or target a Myles Garrett sack prop at plus odds.
- Over bettors can ladder alternate totals, but beware a late-game middle if the number moves.
Late Sunday Window:
Detroit Lions @ Green Bay Packers – Sun., Sept 7 — 4:25 p.m. ET (CBS)
- Lambeau opens with Green Bay –1.5 and a near-pick’em ML (Packers –104, Lions –114); total 49.5.
- Lions backers who trust Jared Goff can take the modest plus spread or pivot to an alternate line (–1.5) at plus money; Packers bettors may tease GB to +4.5 or pair a Jordan Love anytime-TD prop with the over.
- The outcome will jolt NFC North futures after just 60 minutes.
Sunday Night Football:
Baltimore Ravens @ Buffalo Bills – Sun., Sept 7 — 8:20 p.m. ET (NBC)
- Prime-time NFL odds give Buffalo a 1.5-point edge (–123 ML) with Week 1’s highest total at 51.5.
- Ravens believers can back Lamar Jackson at +104 ML or tease Baltimore to +7.5 alongside the under.
- Bills bettors wary of juice may flip to an alternate spread (–4.5) at plus money; live-bettors could hunt a middle if early drives stall and the total dips.
Monday Night Football:
Minnesota Vikings @ Chicago Bears – Mon., Sept 8 — 8:15 p.m. ET (ABC)
- Soldier Field finale opens with Minnesota –1.5 and a –107 ML; Chicago sits –112 in a virtual pick’em, total 44.5.
- Bears backers banking on Caleb Williams can grab the slight plus price or wedge Chicago +1.5 into a teaser; Vikings bettors might buy the half-point to –1 and trust J.J. McCarthy.
- Rookie-QB props—TD passes, interceptions, rushing yards—should see strong interest and move win-total futures for both teams.
NFL Week 1 Schedule & How To Watch
(All times Eastern)
Thursday, September 4th, 2025
- Dallas Cowboys at Philadelphia Eagles – 8:20 p.m. – NBC · Peacock
Friday, September 5th, 2025
- Kansas City Chiefs vs Los Angeles Chargers — SÃO PAULO, BR – 8:00 p.m. – YouTube (global stream)
Sunday, September 7th, 2025 — 1 p.m. window
- Las Vegas Raiders at New England Patriots – 1:00 p.m. – CBS · Paramount+
- Pittsburgh Steelers at New York Jets – 1:00 p.m. – CBS · Paramount+
- Miami Dolphins at Indianapolis Colts – 1:00 p.m. – CBS · Paramount+
- Arizona Cardinals at New Orleans Saints – 1:00 p.m. – CBS · Paramount+
- New York Giants at Washington Commanders – 1:00 p.m. – FOX · Fox Sports app
- Carolina Panthers at Jacksonville Jaguars – 1:00 p.m. – FOX · Fox Sports app
- Cincinnati Bengals at Cleveland Browns – 1:00 p.m. – FOX · Fox Sports app
- Tampa Bay Buccaneers at Atlanta Falcons – 1:00 p.m. – FOX · Fox Sports app
Sunday, Septembr 7th. — 4 p.m. window
- Tennessee Titans at Denver Broncos – 4:05 p.m. – FOX · Fox Sports app
- San Francisco 49ers at Seattle Seahawks – 4:05 p.m. – FOX · Fox Sports app
- Detroit Lions at Green Bay Packers – 4:25 p.m. – CBS · Paramount+
- Houston Texans at Los Angeles Rams – 4:25 p.m. – CBS · Paramount+
Sunday Night Football
- Baltimore Ravens at Buffalo Bills – 8:20 p.m. – NBC · Peacock
Monday Night Football, September 8th, 2025
- Minnesota Vikings at Chicago Bears – 8:15 p.m. – ABC
How to Watch NFL Week 1, 2025
- NBC & Peacock: Season-opening Thursday and the Sunday-night game stream live nationwide on Peacock with a TV provider login or a standalone subscription.
- YouTube (International Game): The Chiefs-Chargers Friday night matchup streams exclusively on the NFL’s official YouTube channel worldwide.
- CBS / Paramount+: Every CBS-televised Sunday afternoon game is available live on Paramount+ in local markets.
- FOX & Fox Sports app: FOX afternoon games stream for authenticated users in the Fox Sports mobile and CTV apps; the network is also preparing to add coverage to its forthcoming Fox One service.
- ABC (Monday Night Football): The Monday opener airs on ABC and streams in the ESPN app with pay-TV credentials.
- Cord-cutter bundles: YouTube TV, Fubo, Hulu + Live TV, and DirecTV Stream carry NBC, CBS, FOX, and ABC, giving access to the full Week 1 lineup.
- NFL+ (mobile): Live local and prime-time games on phones/tablets plus NFL RedZone during Sunday afternoon windows.
What are the favorite types of bets for NFL Week 1?
NFL odds have different categories.
- NFL Spread: One team is the favorite, and that squad can be found with a number and a minus sign next to its points; another is the underdog, and that team will have a plus sign next to its NFL line.
For example, the Buffalo Bills are -1½ points against the Baltimore Ravens. John Harbaugh’s team is +1½ points; this means the Bills have to win the game by two points or more to win a bet. The Ravens would have to win the game outright or lose by a point to cash. ATS odds can be found on all NFL games.
- NFL Moneyline: Also factors in plus and minus signs. A favorite would be minus on a money line, that means Buffalo could be -115, which means one would have to bet $115 to win $100. In the Ravens’ case, they could be +110, which would translate to betting $100 to win $110.
- NFL Totals (over/under): This is an NFL line that is set for the amount of points a bettor believes will be scored, say the total in a game between Teams A&B is 37½ points, the person making the wager determines whether the final score in the game will be more or less than that number of points. Over is more than 37½, and Under is less than 37½.
What key factors influence the setting of NFL Week 1 odds?
NFL odds Week 1 are influenced by what teams did in the previous season and offseason. While the prior campaign doesn’t always dictate success or failure in the next one, it does provide a barometer for how a team has done.
Add in other factors like coaching changes, free-agent signings, trades, and draft picks, and BetUS and all other sportsbooks have a gauge to make a line. Throw in where the game is played, who is home, and who is away, and the thought process can be completed. NFL Week 1 Odds & Betting Lines are a great chance to find the spot to make plays before the season takes its shape.
NFL Odds Week 2 are determined in a big way by what happens in Week 1. Who wins, who loses, what players thrive, and which ones nosedive.
Additionally, home-field advantage influences the decision on where to set the ATS and moneyline. And depending on how many points were scored by teams in Week 1 games, that could impact the totals for Week 2.
What are other types of bets for NFL Week 1?
As mentioned, common types of bets for NFL Week 1 are ATS, Moneyline, and Totals. There are also numerous options in the prop market, and one can tie wagers together on the same game or different ones by making plays.
An aside to NFL Week 1 bets, are futures. They can be found on BetUS and provide opportunities to bet on teams one thinks will win the Super Bowl.
To cash an NFL Super Bowl odds bet, the team you bet on has to win the NFL championship game. The futures markets fluctuate depending on what happens in the offseason and are adjusted week-to-week based on news and game results.
Why Choose BetUS for NFL Betting
Our user-friendly NFL betting platform makes it a breeze to navigate through all the NFL Week 1 odds. Whether you’re looking to place a spread bet, back your favorite team on the moneyline, or wager on the game total, you’ll find all these options and more just a few clicks away. For those seeking even more excitement, explore our wide range of game props that let you bet on specific player performances, team statistics, and game events.
We pride ourselves on offering up-to-the-minute NFL Week 1 odds that reflect the latest NFL news, injury reports, and team developments. This ensures that you always have access to the most current lines when you’re ready to place your bets. Our mobile-optimized site allows you to check odds and make wagers on the go, so you never miss out on a great betting opportunity.
