San Francisco travels to Lumen Field for the first of two NFC West meetings this season, a rematch of the game that ended its last campaign. Check the latest NFL odds as you follow along. Seattle leads the all-time series 33-24, including a 2-1 edge in the playoffs. The Seahawks have won the last two meetings: 13-3 in the Week 18 game in Santa Clara, then 41-6 in the NFC Divisional Round on January 17, 2026, the second-worst playoff loss in 49ers history.
Through three weeks this season, the 49ers were 3-0 and led the NFL in yards per play, while the Seahawks were 2-1. Seattle won a franchise-tying 14 games in 2025, and the teams meet again in Week 12 in Santa Clara. San Francisco gets a chance to answer that January result right away.
49ers at Seahawks Match Details
Game: Sunday, October 11, 2026
Kickoff: 4:25 PM ET
Venue: Lumen Field, Seattle, WA
Broadcast: FOX
Records (through Week 3): 49ers 3-0 / Seahawks 2-1
Storyline: Seattle leads the all-time series 33-24 and has won the last two meetings, including a 41-6 playoff win in January. The teams meet again in Week 12.
Spread Analysis
The last two meetings were decided by 10 and 35 points, both in Seattle’s favor, so the 49ers arrive with a result to avenge. With a second meeting already scheduled, both staffs will be thinking about how much to show this early in the season.
Total Betting Trends
The last two meetings produced 16 and 47 combined points, so the series has gone both low and high recently. For anyone following the over/under conversation, the 49ers’ early-season offensive output is worth weighing against Seattle’s defensive performance in those two wins.
