A key NFC West rivalry takes the spotlight in NFL Week 5 as the San Francisco 49ers travel to Lumen Field to face the Seattle Seahawks. NFL odds have the 49ers as 2½-point road favorites at -2½ (-110), while the Seahawks are +2½ (-110) at home. The total is set at 47½ points, with both the Over and Under priced at -110.
San Francisco enters as a slight road favorite in what projects to be a competitive divisional battle. The 49ers are expected to have the edge due to their offensive weapons and recent success, but Seattle remains a dangerous home underdog capable of making this a close contest. The 2½-point spread keeps both teams firmly in play, while the total of 47½ points suggests oddsmakers expect an entertaining matchup with scoring opportunities on both sides of the ball.
- Game: Thursday, October 8, 2026 at 8:15 PM ET
- Spread: 49ers -2½ (-110) / Seahawks +2½ (-110)
- Total: 47½ (-110 both sides)