The Indianapolis Colts travel to Jacksonville for a Week 8 AFC South showdown against the Jaguars. NFL odds have Jacksonville as a -4½ points home favorite at -4½ (-110), while Indianapolis gets the points at +4½ (-110) in a divisional matchup that could have an impact on the standings.
The total of 49½ points points toward a competitive game where every possession could prove important. A field-goal spread keeps this matchup firmly within one-score territory, giving Indianapolis value as a potential road underdog while Jacksonville looks to take advantage of its home field. Divisional games are often closely contested, making this one an attractive betting option for spread and total bettors alike.
- Game: Sunday, November 1, 2026 at 1:00 PM ET
- Spread: Jaguars -4½ (-110) / Colts +4½ (-110)
- Total: 49½ (-110 both sides)