An AFC showdown highlights the NFL Week 5 schedule as the Indianapolis Colts travel to Acrisure Stadium to face the Pittsburgh Steelers. NFL odds have the Steelers as 2½-point home favorites at -2½ (-110), while the Colts are +2½ (-110) on the road. The total is set at 45½ points, with both the Over and Under priced at -110.
Pittsburgh enters as the slight favorite, with home-field advantage giving the Steelers the edge in what oddsmakers expect to be a competitive matchup. Indianapolis remains a dangerous underdog capable of keeping the game close behind its offensive playmakers and defensive pressure. The 2½-point spread indicates a matchup that could go either way, while the total of 45½ points suggests a balanced contest where key possessions and late-game execution could determine the winner.
- Game: Sunday, October 11, 2026 at 1:00 PM ET
- Spread: Steelers -2½ (-110) / Colts +2½ (-110)
- Total: 45½ (-110 both sides)