An AFC showdown highlights the NFL Week 5 schedule as the Indianapolis Colts travel to Acrisure Stadium to face the Pittsburgh Steelers. NFL odds have the Steelers as 2-point home favorites at -2 (-120), while the Colts are +2 (Ev) on the road. The total is set at 44½ points, with both the Over and Under priced at -110.
Indianapolis travels to Acrisure Stadium for an AFC matchup the Steelers have dominated for most of their history, even though the most recent result went the other way. Check the latest NFL odds as you follow along — Pittsburgh holds a commanding 27-8 edge in the all-time series, including a perfect 5-0 mark in the playoffs, but the Colts won the teams’ last meeting 30-13 in December 2023, their third-largest victory in series history.
That result broke a stretch in which Indianapolis had lost its previous three road trips to Pittsburgh, including a narrow one-score defeat the year before. A series this lopsided over the long run doesn’t typically flip on one result, but the Colts now have recent proof they can win decisively in this exact matchup, which adds real weight heading into this rematch.
Colts at Steelers Match Details
- Game: Sunday, October 11, 2026 — 1:00 PM ET
- Venue: Acrisure Stadium, Pittsburgh, PA
- Storyline: Steelers lead the all-time series 27-8, but the Colts won the last meeting 30-13 — their third-biggest win in series history, snapping a stretch of close losses in Pittsburgh
Spread Analysis
A series this lopsided over its full history still produced a blowout in the other direction last time out, which is worth weighing against whatever historical narrative the raw series record might otherwise suggest.
Total Betting Trends
The teams’ last meeting produced 43 combined points in a game that got away from Pittsburgh in the second half, which is a relevant data point for anyone following the over/under conversation on this one.
