An NFC matchup takes the spotlight in NFL Week 5 as the Detroit Lions travel to State Farm Stadium to face the Arizona Cardinals. NFL odds have the Lions as 3½-point road favorites at -3½ (-110), while the Cardinals are +3½ (-110) at home. The total is set at 49½ points, with both the Over and Under priced at -110.
Detroit enters as the road favorite, with oddsmakers expecting the Lions to have the advantage thanks to their offensive firepower and overall roster strength. Arizona remains a competitive home underdog with the opportunity to challenge Detroit by controlling the pace and creating explosive plays. The 3½-point spread suggests a close matchup that could be decided late, while the total of 49½ points points toward a high-scoring contest featuring two offenses capable of putting up points.
- Game: Sunday, October 11, 2026 at 4:25 PM ET
- Spread: Lions -3½ (-110) / Cardinals +3½ (-110)
- Total: 49½ (-110 both sides)