Detroit travels to State Farm Stadium for an NFC matchup in which the Lions have owned recent history. Check the latest NFL odds as you follow along. Detroit leads the all-time series 36-28-6 and is 5-0-1 against Arizona since 2017. The Lions won the most recent meeting 20-13 in Glendale in September 2024. Before that, the Cardinals had won seven straight in the series from 2006 to 2015.
The two teams arrive from different 2025 seasons. Detroit finished 9-8 and averaged 28.3 points per game, while Arizona went 3-14 and allowed 28.7 points per game. That makes it a matchup between one of the league’s more productive offenses and a defense that struggled to stop opponents last year. The Cardinals will be trying to end a streak that has lasted more than a decade.
Lions at Cardinals Match Details
Game: Sunday, October 11, 2026
Kickoff: 4:25 PM ET
Venue: State Farm Stadium, Glendale, AZ
Broadcast: FOX
Storyline: The Lions lead the all-time series 36-28-6, are 5-0-1 against Arizona since 2017, and won the last meeting 20-13 in 2024. Detroit averaged 28.3 points per game in 2025, while Arizona’s defense allowed 28.7.
Spread Analysis
A series in which Detroit hasn’t lost since 2017 gives the Lions a clear record to lean on, but the Cardinals have been competitive at home, and the last meeting in Glendale was a one-score game. Last season’s offensive and defensive scoring numbers also make this a strength-versus-weakness matchup worth weighing.
Total Betting Trends
The last two meetings produced 33 and 42 combined points, both lower than Detroit’s 2025 scoring average would suggest. For anyone following the over/under conversation, the gap between the Lions’ offense and Arizona’s defense is the main variable to weigh against the series’ recent low-scoring results.
