San Francisco heads to Mercedes-Benz Stadium for an NFC matchup in a series that has traded wins in recent years. Check the latest NFL odds as you follow along.
The 49ers won the most recent meeting 20-10 on Sunday Night Football at Levi’s Stadium on October 19, 2025. Before that, the Falcons won 28-14 in Atlanta in October 2022, the 49ers beat Atlanta 31-13 in December 2021, and the Falcons won 29-22 in 2019. Atlanta also won 41-13 at home in December 2016.
Two numbers from last season frame the matchup. The 49ers’ 20 sacks were the fewest in the NFL in 2025, while the Falcons led the league with 13 sacks in the red zone. San Francisco went 12-5 and averaged 25.7 points per game, while Atlanta finished 8-9 and averaged 20.8. The teams have no other meeting on the 2026 schedule.
Storyline: It’s a short week for San Francisco, which played Washington on Monday Night Football on October 19 before flying across the country for a 10:00 AM Pacific kickoff.
49ers vs Falcons Match Details
- Game: Sunday, October 25, 2026
- Kickoff: 1:00 PM ET
- Venue: Mercedes-Benz Stadium, Atlanta, GA
- Broadcast: FOX
Spread Analysis
The last five meetings split 3-2 in Atlanta’s favor, but four of them were decided by 10 points or more, so these games have tended to break open rather than come down to the final drive.
As you check the NFL Week 7 odds, the early-season form strongly favors the visitors: San Francisco was 5-0 and Atlanta 2-3 through Week 5. The scheduling quirk is the counterweight, since the 49ers have five days between games and a body-clock disadvantage.
Total Betting Trends
Combined scoring in the last five meetings ranged from 30 points in October 2025 to 54 points in 2016, with the three most recent games all finishing at 44 or below. Recent meetings have trended lower, though current offensive form matters more than any single pattern in the series.
