Denver heads to the desert for an interconference matchup in one of the most lopsided series in the league. Check our NFL odds as you follow along.
The Broncos hold a 10-1-1 all-time record against the Cardinals and won the most recent meeting 24-15 at home on December 18, 2022. Before that, Denver won 45-10 in Arizona in 2018 and 41-20 at home in 2014, while the Cardinals’ lone win in the series was a 43-13 rout in December 2010. The Broncos also won 37-20 in Arizona in 2006.
Two numbers from last season frame the matchup. Denver’s defense led the NFL with 68 sacks in 2025, and the Broncos finished 14-3 before Bo Nix broke his ankle in the overtime playoff win over the Bills, ending his season. Arizona went 3-14, and the teams have no other meeting on the 2026 schedule.
Storyline: It’s Denver’s first trip to State Farm Stadium since 2018. Across the series, the Broncos have outscored the Cardinals 334-159.
Broncos vs Cardinals Match Details
- Game: Sunday, October 25, 2026
- Kickoff: 4:05 PM ET (2:05 PM local)
- Venue: State Farm Stadium, Glendale, AZ
- Broadcast: CBS
Spread Analysis
Denver has won four of the last five meetings, and four of those five were decided by nine points or more, with the 24-15 game in 2022 the closest.
As you check the NFL Week 7 odds, the early-season form also leans toward the visitors: the Broncos were 3-2 and the Cardinals 1-4 as of October 15.
Arizona is also dealing with injuries, as James Conner is close to practicing but isn’t expected to open his 21-day evaluation window this week.
Total Betting Trends
Combined scoring in the last five meetings ranged from 39 points in 2022 to 61 points in 2014, with the four games before 2022 all reaching at least 55. That said, with these teams meeting only every four years, current offensive form matters far more than any pattern in the series.
