NFL Week 7 features an intriguing interconference clash as the Denver Broncos travel to Arizona to take on the Cardinals. NFL odds have the Broncos as 7½-point road favorites at -7½ (-110), while the Cardinals are +7½ (-110) at home. The total is set at 43½ points, with both the Over and Under priced at -110.
A spread of 7½ points suggests Denver enters the matchup with a significant advantage despite playing on the road, as oddsmakers expect the Broncos to control the contest from start to finish. Arizona, meanwhile, will look to rise to the occasion as a sizable home underdog and keep the game within striking distance. The total of 43½ points points toward a moderately low-scoring affair, where defensive plays and efficiency in the red zone could ultimately decide the outcome.
- Game: Sunday, October 25, 2026 at 4:05 PM ET
- Spread: Broncos -7½ (-110) / Cardinals +7½ (-110)
- Total: 43½ (-110 both sides)